Oral Intake of Hydrogen-rich Water Inhibits Intimal Hyperplasia in Arterialized Vein Grafts in Rats
نویسندگان
چکیده
منابع مشابه
Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts.
AIMS Veins are still the best conduits available for arterial bypass surgery. When these arterialized vein grafts fail, it is often due to the development of intimal hyperplasia (IH). We investigated the feasibility and efficacy of the ex vivo pre-treatment of vein grafts with soluble carbon monoxide (CO) in the inhibition of IH. METHODS AND RESULTS The inferior vena cava was excised from don...
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BACKGROUND Intimal hyperplasia is one of the most important causes of vascular graft failure. Numerous studies have correlated transforming growth factor-β1 (TGF-β1) with extracellular matrix (ECM) deposition, a hallmark of intimal thickening. PRINCIPAL FINDINGS In the present study, we performed immunohistochemistry, RT-PCR, and Western blot to examine the dynamic expression of TGF-β1, TGF-β...
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Venous bypass grafts often fail following arterial implantation due to excessive smooth muscle cells (VSMC) proliferation and consequent intimal hyperplasia (IH). Intercellular communication mediated by Connexins (Cx) regulates differentiation, growth and proliferation in various cell types. Microarray analysis of vein grafts in a model of bilateral rabbit jugular vein graft revealed Cx43 as an...
متن کاملTacrolimus inhibits intimal hyperplasia in arterialised veins in rats.
OBJECTVES We investigated whether tacrolimus (FK506) can inhibit neointimal formation in arterialised vein grafts in rats. METHODS Lewis iliolumbar veins were implanted into the abdominal aorta of isogeneic rats. Animals in the treatment groups had daily intramuscular injections of tacrolimus at 0.2 mg/kg (group B) and 0.1 mg/kg (Group C), respectively. The control group A had no treatment. L...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2012
ISSN: 0022-4804
DOI: 10.1016/j.jss.2011.11.884